Netrin-1 signaling is best described as which of the following types?

Netrin-1 signaling is best described as which of the following types?

• A. Endocrine signaling
• B. Paracrine signaling
• C. Autocrine signaling
• D. Juxtacrine signaling

Answer: (B)

Netrin-1 signaling is local paracrine signaling. It is a secreted cue released by one cell that diffuses through the surrounding extracellular space to affect nearby cells, such as guiding growing neuronal processes. This short-range action is characteristic of paracrine communication, distinguishing it from endocrine signaling (hormones traveling through the bloodstream to distant targets), autocrine signaling (the cell responding to its own secreted signal), and juxtacrine signaling (direct contact via membrane-tounderligand interactions).

Netrin-1 signaling is local paracrine signaling. It is a secreted cue released by one cell that diffuses through the surrounding extracellular space to affect nearby cells, such as guiding growing neuronal processes. This short-range action is characteristic of paracrine communication, distinguishing it from endocrine signaling (hormones traveling through the bloodstream to distant targets), autocrine signaling (the cell responding to its own secreted signal), and juxtacrine signaling (direct contact via membrane-tounderligand interactions).